Friday, November 9, 2012

Gene find turns soldier beetle defense into biotech opportunity

ScienceDaily (Nov. 7, 2012) ? New antibiotic and anti-cancer chemicals may one day be synthesised using biotechnology, following CSIRO's discovery of the three genes that combine to provide soldier beetles with their potent predator defence system.

CSIRO researchers, and a colleague at Sweden's Karolinska Institute, published details of the gene identification breakthrough and potential applications recently in the international journal Nature Communications.

"For the first time, our team has been able to isolate and replicate the three genes that combine to make the potent fatty acid that soldier beetles secrete to ward off predators and infection," said CSIRO Ecosystem Sciences research leader Dr Victoria Haritos.

"This discovery is important because it opens a new way for the unusual fatty acid to be synthesised for potential antibiotic, anti-cancer, or other industrial purposes," Dr Haritos said.

Soldier beetles exude a white viscous fluid from their glands to repel potential attacks from predators, as well as in a wax form to protect against infection.

The team found this fluid contains an exotic fatty acid called dihydromatricaria acid, or DHMA, which is one of a group called polyynes that have known anti-microbial and anti-cancer properties.

While DHMA and similar polyyne fatty acids are found in a wide variety of plants, fungi, liverworts, mosses, marine sponges and algae, these compounds have proved very difficult to manufacture using conventional chemical processes. However, Dr Haritos and her team have developed a way to achieve this.

"We have outlined a method for reproducing these polyyne chemicals in living organisms like yeast, using mild conditions" Dr Haritos said.

Soldier beetles are the only animals reported to contain DHMA. This, together with the observation that the beetles forage on plants (such as daisies) which contain a lot of these types of fatty acids, led to previous incorrect conclusions that the DHMA in soldier beetles was derived from their diet.

"Through our research and the gene differences we have discovered, we now know soldier beetles have evolved this same defensive compound entirely independently of its production in plants and fungi," Dr Haritos said.

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Story Source:

The above story is reprinted from materials provided by CSIRO Australia, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Victoria S. Haritos, Irene Horne, Katherine Damcevski, Karen Glover, Nerida Gibb, Shoko Okada, Mats Hamberg. The convergent evolution of defensive polyacetylenic fatty acid biosynthesis genes in soldier beetles. Nature Communications, 2012; 3: 1150 DOI: 10.1038/ncomms2147

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/BML7UCV9S70/121108104415.htm

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Thursday, November 8, 2012

Sprint picking up spectrum, customers in Midwest from US Cellular

Sprint

Sprint this morning announced that it will acquire from US Cellular 20 MHz of spectrum in the 1900 MHz band in Midwest markets including Chicago, South Bend, Ind., and Champaign, Ill. It'll also get 10 MHz of spectrum in St. Louis. The moves, which are costing Sprint $480 million, will affect some 585,000 USCC customers

Source: Sprint



Source: http://feedproxy.google.com/~r/androidcentral/~3/IQ0CYJXwbfU/story01.htm

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Resilience and Flood Risk ? State of the Planet

By Adam Yukelson and Pablo Freund Lanfranco

Earlier this year, we could count with our hands the number of New Yorkers seriously interested in the topic of flood insurance.

Most of them, in fact, were our colleagues: a team of graduate students at Columbia University?s Earth Institute, who spent a semester researching the potential for flood insurance markets to serve as a tool for risk mitigation from coastal flooding in New York City. The work was commissioned by the Mayor?s Office of Long Term Planning and Sustainability.

flood insurance, New York City

Only half of homes in flood zones, such as Zone A in New York City (which was ordered to evacuate prior to Hurricane Sandy), are insured against flooding.

With an overwhelming majority of scientists projecting increases in the magnitude and frequency of extreme weather events, and after Hurricane Irene struck New York City in the fall of 2011, this was certainly of interest to the mayor?s office.

None of us, of course, could have imagined that less than six months after completing our study, New York City would experience its worst hurricane since its founding in 1624. The unprecedented storm brought water levels to 13.88? at the Battery, smashing the record 11.2? water level set in 1821 ? crippling utilities, bringing the local and regional mass transit systems to a standstill, and leaving untold numbers of people to rebuild their lives.

Now, the event that was dubbed ?Frankenstorm? has brought our research on flood insurance, disturbingly, to life.

As New York Gov. Andrew Cuomo acknowledged last Tuesday, ?We have a new reality when it comes to these weather patterns; we have an old infrastructure, we have old systems. That is not a good combination.?

This is exactly why the flood insurance market, as a tool for change, is of interest to the mayor?s office, and should be considered more widely by other coastal cities. Replacing existing policy won?t be easy. But policymakers would be wise to examine the irreparable damage Sandy has brought to lives and possibly infrastructure, and use this moment to consider the alternative.

As a starting point, we offer the following picture of the current reality in the market for flood insurance:

Our research indicates that New York City, and other vulnerable areas throughout the United States, are significantly underinsured. Only half of homes in the flood-zones, such as Zone A in New York City (which was ordered to evacuate prior to the storm), are insured against flooding. Outside this zone, coverage drops to a mere 1 percent. The problem is that the designated flood-zones have not been updated in years, despite the Federal Emergency Management Agency?s continued effort to do so, and extreme weather events expected to occur every 100 years have become more frequent over the past years.

More importantly, since flood events affect large geographic areas, covering losses in one home with the premiums of other insurance clients in the area is impossible. Moreover, a market failure known as adverse selection occurs, driven by the fact that only those who perceive themselves to be most at risk purchase insurance, resulting in low participation in insurance programs. The result is an almost complete lack of flood insurance products offered by private insurance firms for residential properties. Due to this market failure, the federal government provided a ?patch,? the National Flood Insurance Program.

The federally backed flood insurance program offers policies where no one else will, and extends subsidized premium rates to 1-in-5 policyholders. But this program is not without its pitfalls. One year policy maximums, low awareness of the program and slow progress with reforming building codes have hampered the National Flood Insurance Program from improving flood risk resilience, and since Hurricane Katrina, the program has carried an $18 billion deficit due to the magnitude of losses. The damage from Hurricane Sandy will surely to extend the deficit significantly.

As we see the pictures and listen to the stories of the devastation caused by Sandy, we are reminded that in New York City alone, more than 30,000 properties in the 100-year floodplain are uninsured for flood damage. On top of that, increases in the frequency of these catastrophic events will lead to mounting losses for the federal program, and discourage even more the participation of private insurers in this market.

We hope that our research can help policymakers in New York City and communities that face similar circumstances overhaul the flood insurance markets locally, regionally and perhaps nationally in order to effectively mitigate the growing risk evidenced by the catastrophic effects of Hurricane Sandy.

Rebuilding after the storm will be a long process, but the policies that incentivize the fundamental risk mitigating mechanisms must be rebuilt from the ground up in order for New York, and the countries? vulnerable locations, to emerge with a more viable and resilient path to face nature in the future.

Our research has led to some very specific recommendations for policy makers:

  1. Conduct a detailed market analysis in order to determine the exact number of properties at risk, value at risk and number of insured properties.
  2. Educate the public about the risk of flooding and the availability of insurance.
  3. Improve local government?s cooperation with NFIP program and integrate flood resiliency standards to building code.
  4. Engage the reinsurance industry to activate the private market for flood insurance products and overcome market failures.
  5. Explore the use of catastrophe bonds.

To access the full report, follow the link (pdf).

Adam Yukelson, a graduate of the M.S. Sustainability Management program ?12, is working on a variety of projects aimed at generating societal well-being in the face of disruptive change. Pablo Freund, a graduate of the MSc Sustainability Management program ?12, is managing director of the Buckminster Fuller Institute, working to promote design science to solve humanity?s most pressing problems.

Source: http://blogs.ei.columbia.edu/2012/11/06/resilience-and-flood-risk/

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White Label App Rush: It's All About Choice? | Bluefire Reader

The holiday season is shifting into high gear and so are we. You probably already know about our recent app updates and the great new features we?re delivering. But there?s more! We?ve also been rolling out new white label apps for our growing list of customers worldwide.

While we continue to add new customers in North America, most of our new business is coming from abroad. The growing availability of ebooks from publishers worldwide, the growing range of compelling devices at a variety of price points and the availability of cost effective, branded mobile reading/retailing apps (from Bluefire) are giving booksellers of all kinds a shot at competing in this fast growing market.

Here are the new white label apps that we?ve shipped in the last two months:

International

  • Booktopia Reader (Australia) ??iOS
  • eB?kur?from D3 Midlar ehf (Iceland) ??Android?/?iOS
  • eKitabu (Kenya) ??Android
  • eBook.de Reader from Libre.de Internet GmbH?(Germany) ??Android?/?iOS
  • Kalahari.com Reader from MIH Internet Africa (Proprietary) Limited (South Africa) ??Android?/?iOS
  • Saxo Reader from Saxo.com (Denmark) ??Android?/ iOS
  • VLeBooks Reader from The Little Group (United Kingdom) ??Android?/?iOS

North America

  • Better World Books ??Android?/?iOS
  • HMH eTextbooks from Houghton Mifflin Harcourt ??Android?/?iOS
  • Reader ? eBooks from Sony ??iOS

We think this is an impressive list?and it will grow quite a bit over the next few weeks as we release more new partner apps and update our existing customers to the latest iOS and Android builds.

We?re also seeing our customers use their branded apps to expand their reach beyond the traditional app distribution channels (e.g. the iTunes App Store and the Google Play store). For example,?Hastings?preinstalls their branded app on devices that are sold online and in their stores?giving new device owners an easy way to connect with the company?s impressive goHastings.com online store.

Device manufacturers are also using the Bluefire platform to expand their reach. The?release of the iOS?Reader? app?? eBooks from Sony?gives iPhone, iPad and iPod Touch users access to their Reader Store by Sony purchases, helping?Sony deliver on their goal of giving their customers the freedom?to read the content they love, anytime and anywhere.

Over the past few years we?ve championed the notion of choice. We?re pleased to see that readers have a growing choice of retailers along with a growing choice of reading devices and apps. It?s a good way to start out the holiday season!

- ?Cliff

This entry was posted in Customer Profiles, News by Cliff. Bookmark the permalink.

Source: http://www.bluefirereader.com/blog/?p=308

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Tuesday, October 23, 2012

Another former Armstrong teammate admits doping

OSLO, Norway (AP) ? Norwegian rider Steffen Kjaergaard became the latest former teammate of Lance Armstrong to admit to using banned performance-enhancing drugs.

"I have long thought that it was best for cycling as a sport that I took this (secret) to the grave," Kjaergaard said Tuesday after he acknowledged using EPO and cortisone. "But the last weeks have made me change course for my own sake and tell the truth," Kjaergaard said.

The 39-year-old Kjaergaard rode with Armstrong in the U.S. Postal Service team when the American won the Tour de France in 2000 and 2001. He said he wasn't aware of any of his teammates using banned substances, "but I assume there were others."

On Monday, Armstrong was stripped of his seven Tour de France titles by the International Cycling Union after the U.S. Anti-Doping Agency detailed evidence of drug use and trafficking by his Tour-winning teams.

"I have not directly witnessed anyone else dealing with this. That's why I do not want to expose anyone else," Kjaergaard said.

The USADA report included statements from 11 former Armstrong teammates ? including Floyd Landis, Tyler Hamilton and George Hincapie ? who admitted to using banned substances while riding with the Texan.

Kjaergaard won several Norwegian championships but no major races on the international level. He is now sports director for the Norwegian Cycling Federation, a position that could be at risk because of his doping confession.

"This is a sad day for Norwegian cycling but we wanted to have this out in the light," said Harald Tiedemann Hansen, the president of Norway's anti-doping doping agency.

___

Associated Press writer Jan M. Olsen in Copenhagen, Denmark, contributed to this report.

Source: http://news.yahoo.com/another-former-armstrong-teammate-admits-doping-114037146--spt.html

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Tuesday, October 9, 2012

Muddy Puddles - The Gerber Babies Blog Product Reviews and ...


I've been doing a lot of shopping lately. The seasons have changed and while we are still a few weeks away from cooler days, I am trying to prepare! I have found a few things on various sites, but I still need to buy jackets for the kids and a few other things. I found Muddy Puddles online and noticed a lot of great items that I'd love to buy! Muddy Puddles is the brainchild of a farmer and mother of three. Like many moms, she was?frustrated by the lack of quality waterproof clothing available to keep her kids clean and dry as they played outdoors. Their Glacier Ski Jacket was the first item I'd put on my shopping list. Blue is my favorite color, and this jacket has lots of features! To have the Muddy Puddles name on it, it has to be more than a pretty piece of clothing! The jacket is breathable and genuinely waterproof (not just water resistant) which is vital to stop rain and melting snow getting inside. It??is?adjustable at the cuffs, neck and hem?which will?stop chills blowing in!?I can only think of one bad thing about it. It doesn't come?in my size!!! This year, we are planning to visit my mother-in-law in New York. Since my husband is a snowboarder, you can bet our kids are going to get a taste of that this year! I need proper attire to keep them comfortable and warm. I found Waterproof Snowboots that look like they'll keep their feet nice and warm! They have many other accessories too! I found great prices and a lot of items on sale. I'd love to?buy baby mitts and a hat?for my niece! The Baby Pom Pom Hat would keep her head and ears warm and it's priced so low, I couldn't shop without adding it to my bag!?Unfortunately they don't offer worldwide delivery. You're in luck if you live in the UK or Ireland! If you need quality clothing for boys, girls, toddlers, or infants, check them out! You can find them on Facebook too!

Source: http://2gerberbabies.blogspot.com/2012/10/muddy-puddles-outdoor-clothing-for-kids.html

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Monday, October 8, 2012

Potato, Cheese And Broccoli Bake

Spud Sunday: New Books On The Shelf

on Sunday, October 7, 2012

I think, perhaps, that the nice people at Gill & MacMillan must have known that my (blog) birthday ? which came and went on Friday ? was approaching. In the past month, they have sent me not one ? and, no, not two ? but three newly published cookbooks. Honestly, if they keep this up, they?ll need to send new bookshelves along the next time, and maybe a bigger kitchen too (I am nothing if not an optimist in that regard).

The truth, of course, is that the enjoyment of a new cookbook doesn?t warrant an upgrade to kitchen accommodations as much as it does the availability of a good armchair from which to peruse and plan, followed by a willingness to try something even just a little bit different from your usual fare.

My newly acquired books, written by three lovely Irish ladies, have provided plenty to browse through, and make me wish that I could spend more time cooking than has seemed to happen of late. And if the kindling of the desire to head kitchen-ward is the first, and most essential test of good cookbook, then ? before an apron has been donned or an onion chopped ? these books have passed with flying colours.

Eat like an Italian

A stylish Catherine Fulvio looking all Audrey-Hepburn-like
on the cover of Eat like an Italian

I open Eat Like an Italian at a random page. I find a recipe for broad bean and Pecorino salad on one side and sorrel flan on the other. That?s it, I?m sold. No two ways about it.

Throughout the book, Catherine Fulvio revisits her love of Italian food, and many of the recipes, like swordfish with chilli and orange or fresh fig ice cream, sing of sunshine and another, warmer, place. They also capture that Italian approach to food which honours simple, fresh ingredients, with recipes like spaghetti with roast tomatoes and sage, where the ingredients are few and need little else other than to be sourced at their best and treated with respect. Though the flavours are thoroughly Italian, Catherine does, however, add an Irish accent to proceedings, and her ?Keeping It Local? notes at the end of each recipe recommend ingredients which can be grown or sourced locally from the pick of Irish suppliers. It?s the best of both Irish and Italian worlds.

Sophie Kooks

Sophie Kooks: seems there's more to Sophie Morris
than just cookie dough...

Sophie Morris, founder of Kooky Dough, is a busy young lady, and one who?s fond of a good home-cooked meal of an evening. The result is her first cookery book, Sophie Kooks, where she shares her take on fast and easy fare.

The recipes are arranged by month and presented, for the most part, as a complete meals, like sirloin steak with chilli butter and roast baby potatoes or lamb chops with mint sauce and roast vegetable couscous. There are curries and stir-fries, pasta and bakes ? all straightforward, largely uncomplicated dinners, along with easy baked treats aimed at the busy individual. It?s the kind of book you might turn to if you had a couple of chops, a piece of steak or a few chicken breasts in the fridge and were looking for easy, middle-of-the-week supper ideas, which, let?s be honest, many of us often are.

Domini At Home

Domini Kemp brings some of the best of her Irish Times columns and more to Domini At Home

Domini Kemp?s latest book, Domini At Home: How I Like To Cook, brings more of her streamlined recipes to the table, including her adaptations of recipes from other well-known cooks and chefs ? thus you?ll find Domini?s take on everything from Ottolenghi?s shakshuka to Nigella?s brownies between these covers.

Though Domini?s tone is casual ? she whizzes, bungs, chucks and squishes with seeming abandon ? the recipes often have head-turning style, as with her smoked eel and bacon salad, ham hock terrine with celeriac remoulade and salsa verde, or puy lentils with sundried tomatoes and Cashel blue cheese. The book includes a host of particularly appealing vegetarian dishes, and not just in the dedicated vegetarian section (which features substantial fare like Gruy?re and wild mushroom gratin) but also in the salads and sides section, which has plenty of meat-free options, such as quinoa salad with lime and coriander, or beetroot and celeriac gratin. This section also includes Domini?s rather indulgent cheese and thyme potato pots, a recipe which laces mashed potatoes with butter, cream, Parmesan and Taleggio, and approaches the ratio of dairy products to potato that made Jo?l Robuchon?s potato pur?e legendary. A recipe with my name written all over it, then.

Potato, Cheese and Broccoli Bake

Cheesy potato and broccoli bake

I was drawn, perhaps inexorably and understandably, to the rich cheese and thyme potato pots featured by Domini Kemp in Domini At Home. However, just as Domini has featured recipes adapted from other well-known chefs and cookery writers, so too have I adapted her recipe and used it as the basis for this little number.

I have toned the original mixture down somewhat by replacing the cream with milk (though it?s still plenty rich, believe me) and I also added some garlic, mustard and a base layer of broccoli. The result is substantial enough to make a veggie dish, either on its own or with some fried or baked mushrooms, or to have as an accompaniment to your choice of pork, bacon or poultry.

For the cheese part, Domini recommended Parmesan, along with Taleggio or Ardrahan. I, on the other hand, used Pecorino and some Port Salut (one of the cheeses very kindly sent to me by Superquinn, to mark both their French wine and food sale, which is happening instore until October 23rd, and the revamping of their new Blackrock store). It would certainly also be worth trying some mature cheddar or Gruy?re, or some goats? cheese perhaps, all depending on what you have and what you like.

You?ll need:

  • 600g potatoes, preferably a floury variety
  • salt
  • 250-300g broccoli, trimmed and cut into roughly even-sized florets
  • 200ml milk
  • 2-3 sprigs of thyme
  • 1 large clove garlic, very lightly crushed
  • 50g butter, melted
  • 0.5 tsp dijon or other mustard
  • freshly ground black pepper
  • zest of half a lemon or to taste (optional)
  • 75g Port Salut (or use another cheese such as mature cheddar or Gruy?re), cubed
  • 15g finely grated Parmesan or Pecorino (or try Desmond cheese if you can get it)

You?ll also need:

  • An ovenproof dish, mine was around 20cm x 20cm and 4cm deep. A ricer is also handy for dealing with the potato mashing side of things.

The Steps:

  • Preheat your oven to 180C.
  • Steam or boil your potatoes in well salted water until just fork tender.
  • While the potatoes are cooking, bring another pot of salted water to the boil and drop in the broccoli florets. Once the water has started to bubble again, cook for 1 minute, then drain and rinse well under cold running water.
  • When the potatoes are done, drain well and return them to the saucepan. Then either let them sit, covered by a tea-towel, for about 5 minutes or place the pan over a low heat for a minute or so while they dry out.
  • Add the milk to a small, heavy saucepan, along with the thyme and garlic. Bring just to the point of boiling, then remove from the heat.
  • Peel your potatoes if you haven?t already done so and put them through a potato ricer, if you have one, or mash with a potato masher or fork. Pour in the melted butter and stir through. Strain the milk to remove the thyme and garlic and then stir into the potatoes to create a loose mash.
  • Add the mustard, black pepper and lemon zest to taste and additional salt if it needs it. Stir in the cubed Port Salut (or whatever cheese you are using).
  • Spread your broccoli florets in a layer in your ovenproof dish. Pour over the potato and cheese mixture, but leave a few green bits peeking out. Sprinkle with the grated Parmesan or Pecorino and bake for around 25 minutes, until just starting to brown. Serve warm on its own or with baked mushrooms or your favourite piece of pork or bacon.

The Variations:

  • Toasted pine nuts or toasted hazelnuts would, I think, be a good addition to the mash and you could certainly try replacing the broccoli with cauliflower or use a mixture of both.

The Results:

Source: http://www.thedailyspud.com/2012/10/07/potato-cheese-broccoli-bake/?utm_source=rss&utm_medium=rss&utm_campaign=potato-cheese-broccoli-bake

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