Tuesday, September 25, 2012

Ravens Receiver Leads Team to Win After Learning of Brother's ...

7:56 pm ET September 24, 2012

Ravens

Less than 24 hours before last night?s game, Baltimore Ravens receiver Torrey Smith?s 19-year-old brother died in a motorcycle crash. Smith played through the heartache, helping the Ravens win a come-from-behind victory against the New England Patriots. He caught six passes for 127 yards and two touchdowns. Family members said Smith wanted to do it for his little brother and he told the press later, ?I didn?t want to hurt my team.?

Source: http://foxnewsinsider.com/2012/09/24/ravens-receiver-leads-team-to-win-after-learning-of-brothers-untimely-death/

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In Europe crisis, connection culture stifles youth

(AP) ? Maria Adele Carrai has two master's degrees from Italian universities in economics and Asian languages and is now earning her Ph.D. in international law in Hong Kong. Her linguistic credentials are formidable: Besides native Italian, she has nearly flawless English, a rarity in Italy, as well as French, Arabic, Japanese and Mandarin.

But the 26-year-old from a family of physicians in a small town near the Adriatic Sea, lacks an increasingly crucial key to unlocking the door to work in Italy: a "raccomandazione." It's Italian for the right word from the right person to get you hired, even if you might not be the best one for the job.

As Europe's economic crisis darkens the future of millions of youth, the culture of connections that has lain at the heart of hiring practices in much of the continent is becoming ever more entrenched, even as it harms prospects of recovery. It is blocking young talent or driving it overseas, and contributing to a vicious circle of stagnation that threatens to leave Europe behind in the game of globalization.

___

Editors: This is the latest installment in Class of 2012, an exploration of Europe's financial crisis through the eyes of young people emerging from the cocoon of student life into the worst downturn the continent has seen since the end of World War II.

___

"What matters is not how good you are, but who you know," laments Carrai, who first spoke to the AP for a Class of 2012 story on the continent's devastating brain drain. To be sure, having a good connection never hurts, anytime, anywhere. But in much of Europe, especially the crisis-hammered south, it's often the main ticket to economic opportunity: Without one, young people and experts say, there's little chance of being launched on a promising career.

Marco Pacetti, rector of Ancona's Polytechnical University, puts it this way: "In the U.S. ... connections matter, but you'd better be good. In Italy, nobody counts on the one with the connection to have competence, merit."

"That's the difference between a letter of recommendation and a 'raccomandazione,'" Pacetti says with a wry chuckle. In America, "the letter writer takes on the responsibility of sending over someone who is well prepared ? who's not an idiot."

A scandal at Rome's Sapienza, one of Italy's oldest and best-known universities, drives home the point. In a case dubbed "relative-gate," the wife, daughter and son of Sapienza's longtime rector landed prestigious teaching posts despite having limited qualifications. The real shocker came when it emerged that the rector's son passed his cardiology exam thanks to an examining panel made up of three dentists and two dental hygienists.

Spain has its own deep-rooted system of connections ? called "enchufismo." As in Italy, it's an outgrowth of a Mediterranean culture of family networks where members of the clan look out for each other. Many southern Europeans have a practically inbred distrust of the state, often associated with corruption ? and family is the one institution they can count on.

Connections became less critical during Spain's economic boom from the late 1990s until 2008, but are now proving crucial again in a country with unemployment at nearly 25 percent.

"In Spain, you always had 'enchufismo,' but at least in boom times you had access to interviews and work (without connections)," said Maria Astilleros, an unemployed teacher in Madrid. "Since the crisis hit, the interviews have ended and we've gone back to 'enchufismo.'"

Astilleros recently secured her first job interview in two years, with a public relations company, because the owner is a client of her uncle.

Gayle Allard, an American professor of managerial economics at the IE Business School in Madrid, estimated that about 95 percent of jobs in Spain depend on connections.

"It was one of the things that shocked me in Spain," said Allard, "that you could only move around in the labor market with contacts."

The professor said that such an ingrained culture of nepotism has a corrosive effect on economic growth, which is more crucial than ever as Spain reels under staggeringly high youth unemployment of nearly 53 percent. Spain is "definitely not a meritocracy," Allard said. "You're probably not getting the best qualified candidate for a job. You're just getting the candidate with the best contacts."

Class of 2012 member Moira Koffi, who recently completed her studies at the prestigious Sorbonne university in Paris, talks about the importance of connections in France: "If you are recommended by someone, it's the first thing you say: It's how you get a job."

While Koffi, a 22-year-old communications grad, has herself benefited from the system, she still wishes connections weren't so decisive in finding employment. "In the U.S.," Koffi said, "people give you a chance because of what you are."

Sorbonne sociology professor Jean-Francois Amadieu said that 70 percent of French people find a job through personal connections or through an internship ? which itself is usually only possible with the right connection. "Youths from modest backgrounds have great difficulties finding internships compare to those from the middle or wealthy classes because of more restricted family networks," he said.

In Italy, the connections culture "has grown even more with the worsening of the economic crisis," said economist Emiliano Mandrone. He's well-positioned to know: Every year, Mandrone helps prepare a state-funded telephone survey of some 40,000 citizens to learn how Italians find their jobs.

"The issue of 'raccomandazioni' isn't, do you find work or don't you," said Mandrone. "Rather, the problem is, you take work away from someone who is better."

Mandrone said the price of the "raccomandazione" system to Italian society and economy has not been quantified in financial terms, but it's clearly "huge."

Italy's connections culture has long been blamed in large part for spurring the "brain drain" of many of Italy's best and brightest. The Institute for Competitiveness, a non-profit Italian think tank, recently estimated that brain drain costs Italy some euros 1.2 billion (more than $1.5 billion) annually in terms of lost patent and other royalties from inventions that highly qualified emigrants from Italy developed while working abroad.

In Greece, ground zero for Europe's financial crisis, a vast connections-based political machine is seen as a major factor in the economic implosion. In return for votes, the major parties slotted job seekers with political connections into cushy bureaucratic jobs ? with little experience or qualifications.

The result: When the financial crisis erupted in late 2009, the government didn't even know how many people it had on its payroll or how much it was paying them.

Germany may be an exception to the trend of European talent taking flight or being stymied in realizing professional dreams. In former communist East Germany, who you knew in the party apparatus was very important to climbing the economic ladder. But in today's united Germany, connections are not seen as a major part of corporate culture.

Class of 2012 member Lutz Hentschel, 27, who completed his master's in electrical engineering earlier this year, sent out about 40 applications before landing a job in Berlin developing electrical circuits for elevators.

During his job hunt, he said, he was once interviewed for a job that ultimately went to a less qualified applicant who knew the interviewer.

But, in Germany, said Hentschel, "if you are qualified, you will get a job in the end,"

Britain grapples with another longstanding system of patronage ? its "old school tie network" that conjures up images of men sporting school blazers or hobnobbing in exclusive gentleman's clubs. While Britain has made great strides in becoming more meritocratic, complaints remain rife that access to prestigious jobs often relies on upper-crust social background and education.

In southern Europe, however, the culture of "raccommandazioni" permeates all social classes and sectors ? from landing a job in a bank to winning a building contract.

Carrai, the linguist and aspiring international law expert, ruefully learned how much connections count even in the rarefied world of academia. She moved to Hong Kong to escape the stifling atmosphere of university nepotism: "I saw how it worked. I didn't want to stay in Italy and stick with this system."

"'Raccomandazioni' are to a certain degree a normal, human," she said. But cross a certain line "and it becomes corruption."

___

AP reporters David Stringer in London, Greg Keller in Paris, Barry Hatton in Lisbon, Portugal, Alan Clendenning in Madrid, Spain, David Rising in Berlin, Derek Gatopoulos in Athens, and Paola Barisani in Rome contributed to this report.

___

Follow The Class of 2012 on the AP Big Story page:

http://bigstory.ap.org/topic/class-2012

___

Follow The Class of 2012 on Twitter:

https://twitter.com/(hash)!/AP/class-of-2012

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2012-09-24-Class-of-2012-The-Right-Connection/id-b4624810c784473aa31d62add038b8e2

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Follow These Hints For Easy Home Improvement | AulaParty Blog

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Source: http://aulaparty.com/follow-these-hints-for-easy-home-improvement

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Karl Guenther Column: Michigan Agriculture - AM 590 - FM 96.5 ...

Michigan Agriculture, second place contributor to our state?s economy, provider of one in four or five jobs in the state, is on the verge of growing, if not exponentially, (that would be a lot!) then at least significantly.? That?s according to? ?Project 2025?, a report by the?East Lansing?based Michigan Agri-Business Association.? The report predicts crop yields will continue growing because of technological advances in seed and crop management.? Beyond that, overall production is forecast to increase because of increased acreage availability.That?s pretty interesting, considering the constant drumbeat of the doom-sayers, bemoaning ?paving over of prime farmland?.

Ignoring that for the moment, we do need to look more closely at another concern, also in the ?Project 2025? report.? That has to do with ?infrastructure challenges? that could limit growth, threaten existing investments and restrict our ability to compete in the global economy.

Now - - if you?re looking for a challenge to which you can devote your unique talents, whatever they may be - - here?s a list:? Infrastructure, in this report, refers to: Rail Transportation, Roads and Bridges, Water Issues, including irrigation and transportation, Utility Access, Broadband Access,? and, one that may be a little more difficult to pinpoint, Talent and Workforce issues.

To follow up on these matters, check it out with the Michigan Agri-Business Association. The Association?s WEB address is:?www.miagbiz.org.

To further support this concept of continual expansion of?Michigan?s agriculture, contemplate an October 23d planned event.? It?s being billed as the first Export Promotion Event in?Michigan?to include agriculture in a full-service export forum. Reflecting its?Southwest Michigan?sphere of influence, the Export Promotion event is to be held in Allegan, at the Allegan County Facility,?3255 122nd Avenue.? It?s being put together by BC CAL KAL Inland Port Development Corporation.? That?s?Battle Creek,?Calhoun?County,?Kalamazoo?County.? The whole thing is intended to assist small and medium-sized business get access to government funding, best utilize international freight forwarding and logistics, export industrial or agricultural products and consider Foreign-Trade Zones for global advantage.

The panel of experts includes George Erickcek, Upjohn Institute for Employment Research; Maureen Lyon who heads the State Trade Export Promotion Program for Michigan Economic Development Corporation, and Dr. Donna LaCourt, also MEDC, specialist in International Trade and Agriculture and Rural Development.

And this I predict:? No matter who wins the Presidential Election, Michigan Agriculture will survive, and thrive!!

Karl Guenther is a retired farm broadcaster at WKZO and can be reached at?khguenther@charter.net. He is a member of Michigan Farm Bureau and an emeritus member of the National Association of Farm Broadcasting.

Source: http://wkzo.com/news/articles/2012/sep/24/karl-guenther-column-michigan-agriculture/

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The Long and Disreputable History of Repressing the Black Vote (Atlantic Politics Channel)

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Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/250629003?client_source=feed&format=rss

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Monday, September 24, 2012

Early Childhood Education: No Place for Men? ? Organizations ...

Even after years of studying gender as a sociologist, I was not prepared to see a man in the infant room on my daughters? first day at a new child care center in August 2011.? I assumed the man was a dad.? When my three year old happily introduced me to ?Teacher Adam? the next day, I realized that he was the first male child-care worker I had ever met (thus, my Biblically-based pseudonym for him? ?Adam?).? I left the center very pleased that my family had chosen a seemingly progressive child-care facility in the small California city to which we had just moved.

I soon found out that not all of the parents or female staff were so pleased.? These staff and parents believe that men should not care for small children, especially infants, in a child-care facility, and that any man who wants to do so is a pedophile.? Thanks to their beliefs, Adam, the only man ever to be hired in the 25 year history of my daughters? child-care center, no longer works there.? In fact, he will no longer be able to work with children ever again.

The mistrust of male child-care workers is a widespread phenomenon.? Ronald V. McGuckin ?aka ?The Child Care Lawyer,? said that in his 30 years of professional experience male caregivers have been more subject to the fear and scrutiny of parents of young children than have female caregivers, especially with regard to changing diapers and potty training.

Returning to my own situation, it was a female staff member?s conviction that men should not change diapers that compelled her and others to keep a careful eye on Adam at the center.? Their sexist paranoia led one of them to suspect Adam of having an erection after bouncing an infant on his lap.? This suspicion, once reported, not only ended Adam?s career in early childhood education, but also the career of the center?s director who had hired him.

Neither private nor state investigations concluded that Adam was guilty of sexual abuse.? Also ignored was the opinion that many staff and families (including mine) found a state investigator to ask leading questions and twist our words.

After reading the state investigation report, many parents had made up their minds:? Adam was a threat to children everywhere because he is a man.

Even though the director denied having heard prior complaints about Adam?s conduct, at a meeting she held with parents, her denial fell on deaf ears.? The majority of parents put all their faith in the content of the poorly written state report.

The Community Care Licensing Division of California now intends to prevent Adam from ever working at a child-care facility again.

In less than five months, Adam went from being one of the best-loved teachers among the children at my daughters? child care center to a complete outcast in the field of early childhood education.? Such is the power of our society?s fear of male child-care workers.? It?s a small wonder then that men make up only 5.2 percent of child care workers and a mere 3 percent of pre-school teachers in the U.S.

While men in other female-dominated professions experience what sociologist Christine Williams calls a ?glass escalator? ?quick promotions to the top administrative positions in their fields, based primarily on their sex, Adam?s case leads me to believe there is no such glass escalator for men in early childhood education.? How can a man rise to an administrative role in a field requiring care for children if he is not trusted with children?s basic care?? Even directors must often change diapers, help children use the toilet, and put children down for naps.

And maybe that?s what distinguishes early childhood education from other female-dominated professions.? The entire field, from caregiver to director, is hands-on, service-oriented care for children.? Declaring men unfit to provide such care is not only about sexism against men, however.? It?s also about sexism against women.? The greater the fear of men in caring professions, the more women are left to shoulder the responsibility of care work.? If women experienced equality in all professions, then perhaps they wouldn?t regard child care as their exclusive domain, and wouldn?t feel threatened by the participation of men. After all, without glass ceilings for women, there would be no glass escalators for men.

But without more men in child care centers, how are stereotypes about them going to break?? How can we teach U.S. children not to regard early childhood education as the exclusive domain of women, when they see only women caring for them?? What message are we sending today?s youth when we glorify involved fathers and stay-at-home dads but vilify male child-care workers?? Other nations are tackling these questions head on, by holding conferences on men in early childhood education and encouraging more men to enter the field.? I think it?s high time the U.S. did the same, so that seeing men like Adam with our nation?s children is a cause for celebration, not fear.

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Source: http://oowsection.org/2012/09/22/early-childhood-education-no-place-for-men/

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Roche underscores leadership in oncology with new data in HER2 ...

Publication date: 24 September 2012
Author:?

Tagged with: Breast cancer, ESMO 2012, Roche

Roche has announced that data on thirteen of its investigational and approved products will be presented at the European Society for Medical Oncology (ESMO) Congress taking place in Vienna, Austria on 28 September ? 2 October 2012.

During the past 50 years Roche has developed and secured approval for ten cancer medicines. The data presented at ESMO 2012 reflect not only the continuing role being played by Roche?s early discoveries, but also the potential of the company?s newer treatments. Highlights will include data on personalised medicines from the company?s HER2 and skin cancer franchises

?Our mission is to develop therapies that transform medicine,? said Hal Barron M.D., Chief Medical Officer and Head, Global Product Development. ?The improvement in survival with trastuzumab emtansine (T-DM1) and other data presented at ESMO reflect our commitment to make a real difference for people living with cancer.?

HER2-positive breast cancer

Since it was first licensed in 1998, Herceptin has become the foundation of care in HER2-positive breast cancer. Data presented at ESMO 2012 will reflect both the pivotal role Herceptin continues to play, but also highlights how decades of research into HER2-positive cancer is enabling Roche to lead the next wave of developments that may further improve the treatment and outcomes for women with this aggressive disease:

Further results including overall survival data will be presented from the Phase III EMILIA study. The trial compared trastuzumab emtansine (T-DM1) to Xeloda plus lapatinib in patients with HER2-positive unresectable locally advanced or metastatic breast cancer who had previously been treated with Herceptin and a taxane chemotherapy.

Roche and the Breast International Group (BIG) will present the final analysis of the 5,000 patient, Phase III HERA (HERceptin Adjuvant) study. The study assessed how adjuvant treatment with Herceptin has impacted the disease free survival (DFS; the time lived without return of the disease) of women with HER2-positive early breast cancer after completion of standard chemotherapy. Data will be presented comparing the DFS of women given Herceptin treatment for two years compared to those treated with Herceptin for one year. In addition, an update will be provided on Herceptin given for one year versus observation after eight years of follow-up.

Results from the PHARE study (run by the French National Cancer Institute), investigating six months versus one year of Herceptin treatment, will also be presented.

Skin cancer

In the past, patients with metastatic melanoma could expect to live for as little as six to nine months after diagnosis. Today, treatments such as Zelboraf (vemurafenib) are helping to stall the growth or spread of the cancer and are enabling patients to survive longer, for the first time extending life expectancy beyond one year for many patients. Despite this progress, more still needs to be done to improve outcomes and to ensure that patients have treatment options at all stages of the disease:

At ESMO 2012, results from a pilot study of 24 patients with BRAF V600 mutation-positive metastatic melanoma and symptomatic brain metastases who were treated with Zelboraf will be presented.

Roche is building on its extensive clinical experience with Zelboraf to investigate a number of combination approaches, which may in the future expand the treatment options available to patients with this incurable disease. At ESMO 2012 the first results from BRIM7, a Phase Ib dose ranging study assessing the potential of combining Zelboraf with the MEK inhibitor GDC-0973 will be presented. Roche will further study the combination of Zelboraf and the MEK inhibitor GDC-0973 in a Phase III clinical investigation.

Key abstract information:

Pre-planned, final analysis of the Phase III HERceptin Adjuvant (HERA) trial (two years versus one year of treatment with Herceptin) (Abstract # LBA6_PR). [Monday 1 October. Hall A, 16.15].

Updated Overall Survival Results from EMILIA, a phase 3 study of trastuzumab emtansine (T-DM1) vs capecitabine (X) and lapatinib (L) in HER2-positive locally advanced or metastatic breast cancer (MBC) (Abstract #LBA 12). [Monday 1 October 2012. Hall A, 14.10].

Phase IB Study of vemurafenib in combination with the MEK inhibitor, GDC-0973, in patients with locally advanced/unresectable or metastatic BRAFV600 mutation positive melanoma. (Abstract # LBA28). [Saturday 29 September. Hall C, 09:30].

Open-label pilot study of vemurafenib in previously treated metastatic melanoma (mM) patients (pts) with symptomatic brain metastases (BM). (Abstract #1125P). [Monday 1 October. Hall XL, 13:00].

About Herceptin

Herceptin (trastuzumab) is a humanised monoclonal antibody, designed to target and block the function of HER2, a protein produced by a specific gene with cancer-causing potential when it is overexpressed. The mode of action of Herceptin is unique in that it activates the body?s immune system and suppresses HER2 signalling to target and destroy the tumour. Herceptin has demonstrated unprecedented efficacy in treating both early and advanced (metastatic) HER2-positive breast cancer. Given on its own as monotherapy as well as in combination with or following standard chemotherapy or following surgery, Herceptin has been shown to improve overall survival, response rates and disease-free survival while maintaining quality of life in women with HER2-positive breast cancer.

A subcutaneous (SC) formulation of Herceptin, administered as a five minute injection under the skin, is currently being investigated. An application for Herceptin SC (vial) formulation has been submitted to some Regulatory Authorities, including EMA and Swissmedic, and is currently under assessment.

Herceptin is marketed in the United States by Genentech, in Japan by Chugai and internationally by Roche. Since 1998, Herceptin has been used to treat more than 1.2 million people with HER2-positive breast cancer worldwide.

About trastuzumab emtansine

Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate (ADC) being studied in HER2-positive cancers. It is comprised of the antibody trastuzumab and the chemotherapy agent DM1 attached together using a stable linker. Trastuzumab emtansine is designed to target and inhibit HER2 signalling, and to deliver the chemotherapy agent DM1 directly inside HER2-positive cancer cells. Trastuzumab emtansine binds to the HER2-positive cancer cells and is thought to block out-of-control signals that make the cancer grow while also calling on the body?s immune system to attack the cancer cells. Once trastuzumab emtansine is absorbed into those cancer cells, it is designed to destroy them by releasing the DM1.

About Zelboraf?

Zelboraf is a personalised oral medicine designed to specifically inhibit the activity of the mutant BRAF protein. It is the first and only approved BRAF inhibitor and has been proven to help patients with BRAF V600 mutation-positive metastatic melanoma in two important ways; it stalls the growth or spread of the cancer (PFS) and helps patients survive longer (OS), for the first time extending life expectancy beyond one year for many patients.

Clinical experience with Zelboraf is growing every day; it is already approved in 40 countries and has been used for the treatment of more than 7000 BRAF V600 mutation-positive metastatic melanoma patients worldwide.

To further enhance the potential treatment options available to patients at all stages of the disease, Roche is building on its extensive clinical experience with Zelboraf to investigate a number of combination approaches, including Zelboraf with the MEK inhibitor GDC-0973 and Zelboraf with immunotherapies.

Zelboraf was co-developed under a 2006 license and collaboration agreement between Roche and Plexxikon, now a member of the Daiichi Sankyo Group.

GDC-0973 [XL518] is a potent, highly selective inhibitor of MEK, a serine/threonine kinase that is a component of the RAS/RAF/MEK/ERK pathway. GDC-0973 is being developed by Genentech, a member of the Roche Group, under a collaboration agreement with Exelixis.

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Source: http://www.europeanpharmaceuticalreview.com/14964/news/industry-news/roche-underscores-leadership-in-oncology-with-new-data-in-her2-positive-breast-cancer-and-skin-cancer/

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